The MA-HPV assay is a clinical sensitive assay with a lower clinical specificity compared with the GP-EIA. The sensitivity of the MA-HPV was noninferior to that of the GP-EIA (P = 0.0001), whereas the specificity of the MA-HPV was inferior (0.89 95% CI, 0.85-0.91 P > 0.99). The present casecontrol association study focused on the cost effective high throughput genotyping using Agena MassARRAY matrix-assisted laser desorption/ionization-time of flight, mass. The relative sensitivity of the MA-HPV assay for cervical intraepithelial neoplasia ≥2 or ≥3 was 1.02 (95% CI, 0.98-1.05) and 1.01 (95% CI, 0.99-1.04), respectively. instruments (5 with 2 retro-fitted for Illumina Infinium X-staining capabilities) Agena Bioscience MassARRAY System Agena Bioscience Nanodispensor. The MassARRAY SARS-CoV-2 Panel is authorized for use with respiratory specimens collected from individuals suspected of COVID-19 by their healthcare provider. The type-specific concordance of the MA-HPV assay was assessed as well. Are you tired of managing trade-offs between sample quality, limited budget. The clinical accuracy of the MA-HPV assay for sensitivity and specificity was assessed relative to that of the general primer 5+/6+ PCR enzyme immunoassay (GP-EIA), by a noninferiority test. The MA-HPV assay was validated using the VALGENT4 panel, which constitutes 997 consecutive samples from a screening population in addition to 297 disease-enriched samples with abnormal cytology findings. The MA-HPV assay is a mass array-based assay that individually detects 14 oncogenic HPV genotypes and five nononcogenic types. Agena Bioscience 255 subscribers 2.
The module is an add-on to the MassARRAY Analyzer.The clinical performance evaluation of the novel MassARRAY human papillomavirus (MA-HPV) assay was performed using Danish SurePath cervical cancer screening samples under the fourth Validation of HPV Genotyping Tests (VALGENT) framework. The Chip prep module can process eight 96-pad SpectroCHIP Arrays in less than a day and it includes on-board cooling and storage, which allow overnight processing and storage of two additional SpectroCHIP Arrays. Scientific Reports - Evaluation of 41 single nucleotide polymorphisms in canine diffuse large B-cell lymphomas using MassARRAY Skip to main content Thank you for visiting. “The addition of the Chip prep module simplifies our process and reduces the potential for contamination,” added Tammy Ray, Medical Technologist for the laboratory. MassARRAY SARS-CoV-2 Panel by Agena Bioscience SARS-CoV-2 Panel For in vitro diagnostic use in the U.S. Bobbie Sutton, Pathologist and Director of Molecular Pathology. “The flexibility to refine complicated testing methods quickly and easily has made the MassARRAY System an integral part of our molecular testing,” said Dr.
South Bend Medical Foundation, an early access site, has realized many of the benefits of the MassARRAY System in their clinical laboratory. High throughput laboratories can capitalize on the quick load-and-go process of the Chip prep module. Placed at the center of your molecular workflow, the MassARRAY System can help you optimize throughput, multiplexing capacity, and data analysis. It automates several processing steps, including dispensing and desalting samples onto the SpectroCHIP® Array, and subsequently loading these onto the MassARRAY Analyzer. The MassARRAY System allows labs to focus on a select set of gene regions that have known or emerging associations with disease, simplifying the genetic testing process. This study has led to the development of a broader range of TaqMan SNV assays, haplotype phasing methodology with TaqMan adaptable for other technologies. The MassARRAY System by Agena Bioscience is a benchtop mass spectrometer that provides sensitive, accurate, and rapid analysis of nucleic acid samples.
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The Chip prep module is designed to minimize hands-on time and reduce the risk of cross contamination associated with manual sample handling. Fragment analysis: The resulting fragments are subjected to MALDI-TOF analysis on a Agena MassARRAY Analyzer, where the mass difference of a fragment between an unmethylated and methylated CpG (16 Daltons, A to G) is resolved and quantified. Agena MassARRAY was also used for CYP2C19.
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